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Blockade of a Laminin-411–Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Sun, Tao ; Patil, Rameshwar ; Galstyan, Anna ; Klymyshyn, Dmytro ; Ding, Hui ; Chesnokova, Alexandra ; Cavenee, Webster K. ; Furnari, Frank B. ; Ljubimov, Vladimir A. ; Shatalova, Ekaterina S. ; Wagner, Shawn ; Li, Debiao ; Mamelak, Adam N. ; Bannykh, Serguei I. ; Patil, Chirag G. ; Rudnick, Jeremy D. ; Hu, Jethro ; Grodzinski, Zachary B. ; Rekechenetskiy, Arthur ; Falahatian, Vida ; Lyubimov, Alexander V. ; Chen, Yongmei L. ; Leoh, Lai S. ; Daniels-Wells, Tracy R. ; Penichet, Manuel L. ; Holler, Eggehard ; Ljubimov, Alexander V. ; Black, Keith L. ; Ljubimova, Julia Y.



Abstract

There is an unmet need for the treatment of glioblastoma multiforme (GBM). The extracellular matrix, including laminins, in the tumor microenvironment is important for tumor invasion and progression. In a panel of 226 patient brain glioma samples, we found a clinical correlation between the expression of tumor vascular laminin-411 (alpha 4 beta 1 gamma 1) with higher tumor grade and with ...

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