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Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation channel

Reichhart, Nadine ; Schöberl, Simon ; Keckeis, Susanne ; Alfaar, Ahmad S. ; Roubeix, Christophe ; Cordes, Magdalena ; Crespo-Garcia, Sergio ; Haeckel, Akvile ; Kociok, Norbert ; Föckler, Renate ; Fels, Gabriele ; Mataruga, Anja ; Rauh, Robert ; Milenkovic, Vladimir M. ; Zühlke, Kerstin ; Klussmann, Enno ; Schellenberger, Eyk ; Strauß, Olaf


Changes in cell function occur by specific patterns of intracellular Ca2+, activating Ca2+-sensitive proteins. The anoctamin (TMEM16) protein family has Ca2+-dependent ion channel activity, which provides transmembrane ion transport, and/or Ca2+-dependent phosphatidyl-scramblase activity. Using amino acid sequence analysis combined with measurements of ion channel function, we clarified the so ...


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