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The agonistic TSPO ligand XBD173 attenuates the glial response thereby protecting inner retinal neurons in a murine model of retinal ischemia

Mages, Kristin ; Grassmann, Felix ; Jägle, Herbert ; Rupprecht, Rainer ; Weber, Bernhard H. F. ; Hauck, Stefanie M. ; Grosche, Antje


Background: Ligand-driven modulation of the mitochondrial translocator protein 18 kDa (TSPO) was recently described to dampen the neuroinflammatory response of microglia in a retinal light damage model resulting in protective effects on photoreceptors. We characterized the effects of the TSPO ligand XBD173 in the postischemic retina focusing on changes in the response pattern of the major glial ...


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