Miner, Kent ; Labitzke, Katja ; Liu, Benxian ; Wang, Paul ; Henckels, Kathryn ; Gaida, Kevin ; Elliott, Robin ; Chen, Jian Jeffrey ; Liu, Longbin ; Leith, Anh ; Trueblood, Esther ; Hensley, Kelly ; Xia, Xing-Zhong ; Homann, Oliver ; Bennett, Brian ; Fiorino, Mike ; Whoriskey, John ; Yu, Gang ; Escobar, Sabine ; Wong, Min ; Born, Teresa L. ; Budelsky, Alison ; Comeau, Mike ; Smith, Dirk ; Phillips, Jonathan 
; Johnston, James A. ; McGivern, Joseph G. ; Weikl, Kerstin ; Powers, David ; Kunzelmann, Karl ; Mohn, Deanna ; Hochheimer, Andreas ; Sullivan, John K.
; Johnston, James A. ; McGivern, Joseph G. ; Weikl, Kerstin ; Powers, David ; Kunzelmann, Karl ; Mohn, Deanna ; Hochheimer, Andreas ; Sullivan, John K. 
Zusammenfassung
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor beta-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. Antagonists of the Ca2+-activated Cl- channel, TMEM16A, offers a new mechanism to bronchodilate airways and block the multiple contractiles operating in severe disease. To identify TMEM16A antagonists we screened a library of ...
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