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Liberal transfusion strategy to prevent mortality and anaemia-associated, ischaemic events in elderly non-cardiac surgical patients – the study design of the LIBERAL-Trial

Meybohm, Patrick ; Lindau, Simone ; Treskatsch, Sascha ; Francis, Roland ; Spies, Claudia ; Velten, Markus ; Wittmann, Maria ; Gueresir, Erdem ; Stoppe, Christian ; Kowark, Ana ; Coburn, Mark ; Selleng, Sixten ; Baschin, Marcel ; Jenichen, Gregor ; Meersch, Melanie ; Ermert, Thomas ; Zarbock, Alexander ; Kranke, Peter ; Kredel, Markus ; Helf, Antonia ; Laufenberg-Feldmann, Rita ; Ferner, Marion ; Wittenmeier, Eva ; Gürtler, Karl-Heinz ; Kienbaum, Peter ; de Abreu, Marcel Gama ; Sander, Michael ; Bauer, Michael ; Seyfried, Timo ; Gruenewald, Matthias ; Choorapoikayil, Suma ; Mueller, Markus M. ; Seifried, Erhard ; Brosteanu, Oana ; Bogatsch, Holger ; Hasenclever, Dirk ; Zacharowski, Kai



Zusammenfassung

Background Perioperative anaemia leads to impaired oxygen supply with a risk of vital organ ischaemia. In healthy and fit individuals, anaemia can be compensated by several mechanisms. Elderly patients, however, have less compensatory mechanisms because of multiple co-morbidities and age-related decline of functional reserves. The purpose of the study is to evaluate whether elderly surgical ...

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