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Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

Schreiber, Rainer ; Buchholz, Björn ; Kraus, Andre ; Schley, Gunnar ; Scholz, Julia ; Ousingsawat, Jiraporn ; Kunzelmann, Karl


Background Transepithelial chloride2 secretion, through the chloride channels cystic fibrosis transmembrane conductance regulator (CFTR) and TMEM16A (anoctamin 1), drives cyst enlargement in polycystic kidney disease (PKD). Polycystic kidneys are hypoxic, and oxidative stress activates TMEM16A. However, mechanisms for channel activation in PKD remain obscure. Methods Using tissue samples from ...


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