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Impact of E-Cadherin and β-Catenin as Prognostic Factor in Renal Cell Carcinoma with Tumor Thrombus of the Vena Cava

Spachmann, Philipp Julian ; Breyer, Johannes ; Kalogirou, Charis ; Lausenmeyer, Eva-Maria ; Weber, Florian ; Prohaska, Sandra ; Denzinger, Stefan ; Burger, Maximilian ; Kübler, Hubert ; Otto, Wolfgang ; Vergho, Daniel


Purpose: Renal cell carcinoma (RCC) forming tumor thrombus (TT) of vena cava (VC) is characterized by poor prognosis. Nevertheless, the outcome of patients after radical surgery varies. To date only limited data concerning prognostic biomarkers in this RCC subgroup are available. Methods: Out of 159 patients with pT3b/c RCC, 95 patients without synchronous distant metastases at time of diagnosis ...


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