Startseite UR

Combined CDK4/6 and Pan-mTOR Inhibition Is Synergistic Against Intrahepatic Cholangiocarcinoma

Song, Xinhua ; Liu, Xianqiong ; Wang, Haichuan ; Wang, Jingxiao ; Qiao, Yu ; Cigliano, Antonio ; Utpatel, Kirsten ; Ribback, Silvia ; Pilo, Maria G. ; Serra, Marina ; Gordan, John D. ; Che, Li ; Zhang, Shanshan ; Cossu, Antonio ; Porcu, Alberto ; Pascale, Rosa M. ; Dombrowski, Frank ; Hu, Hongbo ; Calvisi, Diego F. ; Evert, Matthias ; Chen, Xin



Zusammenfassung

Purpose: Intrahepatic cholangiocarcinoma (ICC) is an aggressive cancer type, lacking effective therapies and associated with a dismal prognosis. Palbociclib is a selective CDK4/6 inhibitor, which has been shown to suppress cell proliferation in many experimental cancer models. Recently, we demonstrated that pan-mTOR inhibitors, such as MLN0128, effectively induce apoptosis, although have limited ...

plus


Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de
0941 943 -4239 oder -69394

Dissertationen: dissertationen@ur.de
0941 943 -3904

Forschungsdaten: datahub@ur.de
0941 943 -5707

Ansprechpartner