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Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8‐methoxypsoralen concentration and by replacing plasma with saline

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Hähnel, Viola ; Brosig, Andreas‐Michael ; Ehrenschwender, Martin ; Burkhardt, Ralph ; Offner, Robert ; Ahrens, Norbert
License: Creative Commons Attribution Non-commercial No Derivatives 4.0
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Date of publication of this fulltext: 09 Sep 2021 04:55


Background Extracorporeal photopheresis (ECP), an apheresis-based therapy for various immunological diseases, works mainly by inducing apoptosis in lymphocytes. Several factors influence the efficacy of ECP with the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet light A (UVA). This study aimed to optimize treatment by varying the 8-MOP starting concentration and the cell suspension ...


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