Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8‐methoxypsoralen concentration and by replacing plasma with saline

URN to cite this document:: urn:nbn:de:bvb:355-epub-492510
DOI to cite this document:: 10.5283/epub.49251

Hähnel, Viola

; Brosig, Andreas‐Michael

; Ehrenschwender, Martin

; Burkhardt, Ralph

; Offner, Robert

; Ahrens, Norbert

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Date of publication of this fulltext: 09 Sep 2021 04:55

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Abstract

Background Extracorporeal photopheresis (ECP), an apheresis-based therapy for various immunological diseases, works mainly by inducing apoptosis in lymphocytes. Several factors influence the efficacy of ECP with the photosensitizer 8-methoxypsoralen (8-MOP) and ultraviolet light A (UVA). This study aimed to optimize treatment by varying the 8-MOP starting concentration and the cell suspension ...