Similar Piperacillin/Tazobactam Target Attainment in Obese versus Nonobese Patients despite Differences in Interstitial Tissue Fluid Pharmacokinetics

URN to cite this document:: urn:nbn:de:bvb:355-epub-493063
DOI to cite this document:: 10.5283/epub.49306

Busse, David

; Simon, Philipp

; Petroff, David ; Dorn, Christoph ; Schmitt, Lisa ; Bindellini, Davide ; Kratzer, Alexander ; Dietrich, Arne ; Zeitlinger, Markus ; Huisinga, Wilhelm

; Michelet, Robin

; Wrigge, Hermann ; Kloft, Charlotte

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Date of publication of this fulltext: 04 Oct 2021 08:54

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Abstract

Precision dosing of piperacillin/tazobactam in obese patients is compromised by sparse information on target-site exposure. We aimed to evaluate the appropriateness of current and alternative piperacillin/tazobactam dosages in obese and nonobese patients. Based on a prospective, controlled clinical trial in 30 surgery patients (15 obese/15 nonobese; 0.5-h infusion of 4 g/0.5 g ...