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Structure of human RNA polymerase III

Ramsay, Ewan Phillip ; Abascal-Palacios, Guillermo ; Daiß, Julia L. ; King, Helen ; Gouge, Jerome ; Pilsl, Michael ; Beuron, Fabienne ; Morris, Edward ; Gunkel, Philip ; Engel, Christoph ; Vannini, Alessandro


In eukaryotes, RNA Polymerase (Pol) III is specialized for the transcription of tRNAs and other short, untranslated RNAs. Pol III is a determinant of cellular growth and lifespan across eukaryotes. Upregulation of Pol III transcription is observed in cancer and causative Pol III mutations have been described in neurodevelopmental disorders and hypersensitivity to viral infection. Here, we report ...


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