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Inducing a stressed phenotype in healthy recipient mice by adoptively transferring CD4+ lymphocytes from mice undergoing chronic psychosocial stress

Amoroso, Mattia ; Kempter, Elena ; Langgartner, Dominik ; Gross, Philipp ; Reber, Stefan O.


Although chronic stress is an acknowledged risk factor for the development of somatic and affective disorders, the cellular and molecular mechanisms underlying stress-induced pathologies are not fully understood. Interestingly, rodent studies involving immune cell transfer suggest that CD4(+) T cells might be at least in part involved in reactivation of a chemically-induced colitis by stress. ...


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