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Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration

Regensburger, Martin ; Stemick, Judith ; Masliah, Eliezer ; Kohl, Zacharias ; Winner, Beate


Dendritic dysfunction is an early event in alpha-synuclein (alpha-syn) mediated neurodegeneration. Altered postsynaptic potential and loss of dendritic spines have been observed in different in vitro and in vivo models of synucleinopathies. The integration of newborn neurons into the hippocampus offers the possibility to study dendrite and spine formation in an adult environment. Specifically, ...


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