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Asp22 drives the protonation state of the Staphylococcus epidermidis glucose/H+ symporter

Seica, Ana Filipa Santos ; Iancu, Cristina V. ; Pfeilschifter, Benedikt ; Madej, M. Gregor ; Choe, Jun-Yong ; Hellwig, Petra


The Staphylococcus epidermidis glucose/H+ symporter (GlcP(Se)) is a membrane transporter highly specific for glucose and a homolog of the human glucose transporters (GLUT, SLC2 family). Most GLUTs and their bacterial counterparts differ in the transport mechanism, adopting uniport and sugar/H+ symport, respectively. Unlike other bacterial GLUT homologs (for example, XylE), GlcP(Se) has a loose ...


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