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Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma

Depner, Martin ; Taft, Diana Hazard ; Kirjavainen, Pirkka V. ; Kalanetra, Karen M. ; Karvonen, Anne M. ; Peschel, Stefanie ; Schmausser-Hechfellner, Elisabeth ; Roduit, Caroline ; Frei, Remo ; Lauener, Roger ; Divaret-Chauveau, Amandine ; Dalphin, Jean-Charles ; Riedler, Josef ; Roponen, Marjut ; Kabesch, Michael ; Renz, Harald ; Pekkanen, Juha ; Farquharson, Freda M. ; Louis, Petra ; Mills, David A. ; von Mutius, Erika ; Ege, Markus J.



Abstract

Growing up on a farm is associated with an asthma-protective effect, but the mechanisms underlying this effect are largely unknown. In the Protection against Allergy: Study in Rural Environments (PASTURE) birth cohort, we modeled maturation using 16S rRNA sequence data of the human gut microbiome in infants from 2 to 12 months of age. The estimated microbiome age (EMA) in 12-month-old infants was ...

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