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Buparlisib modulates PD-L1 expression in head and neck squamous cell carcinoma cell lines

Fiedler, Mathias ; Schulz, Daniela ; Piendl, Gerhard ; Brockhoff, Gero ; Eichberger, Jonas ; Menevse, Ayse-Nur ; Beckhove, Philipp ; Hautmann, Matthias ; Reichert, Torsten E. ; Ettl, Tobias ; Bauer, Richard J.



Abstract

High expression of the immune checkpoint receptor PD-L1 is associated with worse patient outcome in a variety of human cancers, including head and neck squamous cell carcinoma (HNSCC). Binding of PD-L1 with its partner PD-1 generates an inhibitory signal that dampens the immune system. Immunotherapy, that is blocking the PD-1/PD-L1 checkpoint, has proven to be an effective tool in cancer therapy. ...

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