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Heart-Microcirculation Connection

Špiranec Spes, Katarina ; Chen, Wen ; Krebes, Lisa ; Völker, Katharina ; Abeßer, Marco ; Eder Negrin, Petra ; Cellini, Antonella ; Nickel, Alexander ; Nikolaev, Viacheslav O. ; Hofmann, Franz ; Schuh, Kai ; Schweda, Frank ; Kuhn, Michaela


Cardiac ANP (atrial natriuretic peptide) moderates arterial blood pressure. The mechanisms mediating its hypotensive effects are complex and involve inhibition of the renin-angiotensin-aldosterone system, increased natriuresis, endothelial permeability, and vasodilatation. The contribution of the direct vasodilating effects of ANP to blood pressure homeostasis is controversial because variable ...


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