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Two subsets of stem-like CD8+ memory T cell progenitors with distinct fate commitments in humans

Galletti, Giovanni ; De Simone, Gabriele ; Mazza, Emilia M. C. ; Puccio, Simone ; Mezzanotte, Claudia ; Bi, Timothy M. ; Davydov, Alexey N. ; Metsger, Maria ; Scamardella, Eloise ; Alvisi, Giorgia ; De Paoli, Federica ; Zanon, Veronica ; Scarpa, Alice ; Camisa, Barbara ; Colombo, Federico S. ; Anselmo, Achille ; Peano, Clelia ; Polletti, Sara ; Mavilio, Domenico ; Gattinoni, Luca ; Boi, Shannon K. ; Youngblood, Benjamin A. ; Jones, Rhiannon E. ; Baird, Duncan M. ; Gostick, Emma ; Llewellyn-Lacey, Sian ; Ladell, Kristin ; Price, David A. ; Chudakov, Dmitriy M. ; Newell, Evan W. ; Casucci, Monica ; Lugli, Enrico



Abstract

The identity of stem-cell memory progenitor cells has been unclear. Lugli and colleagues use high-dimensional approaches to identify two new progenitor populations of human T cells-one giving rise to a functional lineage, the other to an exhausted-like one. T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors ...

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