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Chemerin Isoform-Specific Effects on Hepatocyte Migration and Immune Cell Inflammation

Feder, Susanne ; Bruckmann, Astrid ; McMullen, Nichole ; Sinal, Christopher J. ; Buechler, Christa



Abstract

Murine chemerin is C-terminally processed to the bioactive isoforms, muChem-156 and muChem-155, among which the longer variant protects from hepatocellular carcinoma (HCC). However, the role of muChem-155 is mostly unknown. Here, we aimed to compare the effects of these isoforms on the proliferation, migration and the secretome of the human hepatocyte cell lines HepG2 and Huh7 and the murine ...

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