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EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer

Rose, Michael ; Maurer, Angela ; Wirtz, Julia ; Bleilevens, Andreas ; Waldmann, Tanja ; Wenz, Maximilian ; Eyll, Marie ; Geelvink, Mirja ; Gereitzig, Melanie ; Rüchel, Nadine ; Denecke, Bernd ; Eltze, Elke ; Herrmann, Edwin ; Toma, Marieta ; Horst, David ; Grimm, Tobias ; Denzinger, Stefan ; Ecke, Thorsten ; Vögeli, Thomas Alexander ; Knuechel, Ruth ; Maurer, Jochen ; Gaisa, Nadine T.



Abstract

Recent findings suggested a benefit of anti-EGFR therapy for basal-like muscle-invasive bladder cancer (MIBC). However, the impact on bladder cancer with substantial squamous differentiation (Sq-BLCA) and especially pure squamous cell carcinoma (SCC) remains unknown. Therefore, we comprehensively characterized pure and mixed Sq-BLCA (n = 125) on genetic and protein expression level, and performed ...

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