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Macrophage Subpopulation Dynamics Shift following Intravenous Infusion of Mesenchymal Stromal Cells

Kosaric, Nina ; Srifa, Waracharee ; Bonham, Clark A. ; Kiwanuka, Harriet ; Chen, Kellen ; Kuehlmann, Britta A. ; Maan, Zeshaan N. ; Noishiki, Chikage ; Porteus, Matthew H. ; Longaker, Michael T. ; Gurtner, Geoffrey C.



Zusammenfassung

Intravenous infusion of mesenchymal stromal cells (MSCs) is thought to be a viable treatment for numerous disorders. Although the intrinsic immunosuppressive ability of MSCs has been credited for this therapeutic effect, their exact impact on endogenous tissue-resident cells following delivery has not been clearly characterized. Moreover, multiple studies have reported pulmonary sequestration of ...

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