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CAMK1D Triggers Immune Resistance of Human Tumor Cells Refractory to Anti–PD-L1 Treatment

Volpin, Valentina ; Michels, Tillmann ; Sorrentino, Antonio ; Menevse, Ayse N. ; Knoll, Gertrud ; Ditz, Madlen ; Milenkovic, Vladimir M. ; Chen, Chih-Yeh ; Rathinasamy, Anchana ; Griewank, Klaus ; Boutros, Michael ; Haferkamp, Sebastian ; Berneburg, Mark ; Wetzel, Christian H. ; Seckinger, Anja ; Hose, Dirk ; Goldschmidt, Hartmut ; Ehrenschwender, Martin ; Witzens-Harig, Mathias ; Szoor, Arpad ; Vereb, Gyorgy ; Khandelwal, Nisit ; Beckhove, Philipp


The success of cancer immunotherapy is limited by resistance to immune checkpoint blockade. We therefore conducted a genetic screen to identify genes that mediated resistance against CTLs in anti-PD-L1 treatment-refractory human tumors. Using PD-L1-positive multiple myeloma cells cocultured with tumor-reactive bone marrow-infiltrating CTL as a model, we identified calcium/calmodulin-dependent ...


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