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SNP dependent modulation of circulating miRNAs from the miR25/93/106 cluster in patients undergoing weight loss

Müller, Stephanie ; Wallner, Stefan ; Schmitz, Gerd ; Loew, Thomas ; Stempfl, Thomas ; Möhle, Christoph ; Strack, Christina ; Sag, Sabine ; Baessler, Andrea ; Fischer, Marcus


Background: Diet induced weight loss represents an intervention for obesity to prevent associated diseases. However there is considerable inter-individual variation. Single nucleotide polymorphisms (SNPs) and plasma miRNA might be contributing factors. We therefore hypothesized that changes in the miRNA pattern during weight loss depend on the SNP genotype. Methods: Plasma miRNA profiles from 12 ...


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