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Vascular occlusion by neutrophil extracellular traps in COVID-19

Leppkes, Moritz ; Knopf, Jasmin ; Naschberger, Elisabeth ; Lindemann, Aylin ; Singh, Jeeshan ; Herrmann, Irmgard ; Stürzl, Michael ; Staats, Léonie ; Mahajan, Aparna ; Schauer, Christine ; Kremer, Anita N. ; Völkl, Simon ; Amann, Kerstin ; Evert, Katja ; Falkeis, Christina ; Wehrfritz, Andreas ; Rieker, Ralf J. ; Hartmann, Arndt ; Kremer, Andreas E. ; Neurath, Markus F. ; Muñoz, Luis E. ; Schett, Georg ; Herrmann, Martin



Zusammenfassung

Background: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. Methods: Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked ...

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