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Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis

Gao, Yixin ; Wang, Ting ; Yu, Xinghao ; Ferrari, Raffaele ; Hernandez, Dena G. ; Nalls, Michael A. ; Rohrer, Jonathan D. ; Ramasamy, Adaikalavan ; Kwok, John B. J. ; Dobson-Stone, Carol ; Brooks, William S. ; Schofield, Peter R. ; Halliday, Glenda M. ; Hodges, John R. ; Piguet, Olivier ; Bartley, Lauren ; Thompson, Elizabeth ; Haan, Eric ; Hernández, Isabel ; Ruiz, Agustín ; Boada, Mercè ; Borroni, Barbara ; Padovani, Alessandro ; Cruchaga, Carlos ; Cairns, Nigel J. ; Benussi, Luisa ; Binetti, Giuliano ; Ghidoni, Roberta ; Forloni, Gianluigi ; Albani, Diego ; Galimberti, Daniela ; Fenoglio, Chiara ; Serpente, Maria ; Scarpini, Elio ; Clarimón, Jordi ; Lleó, Alberto ; Blesa, Rafael ; Waldö, Maria Landqvist ; Nilsson, Karin ; Nilsson, Christer ; Mackenzie, Ian R. A. ; Hsiung, Ging-Yuek R. ; Mann, David M. A. ; Grafman, Jordan ; Morris, Christopher M. ; Attems, Johannes ; Griffiths, Timothy D. ; McKeith, Ian G. ; Thomas, Alan J. ; Pietrini, Pietro ; Huey, Edward D. ; Wassermann, Eric M. ; Baborie, Atik ; Jaros, Evelyn ; Tierney, Michael C. ; Pastor, Pau ; Razquin, Cristina ; Ortega-Cubero, Sara ; Alonso, Elena ; Perneczky, Robert ; Diehl-Schmid, Janine ; Alexopoulos, Panagiotis ; Kurz, Alexander ; Rainero, Innocenzo ; Rubino, Elisa ; Pinessi, Lorenzo ; Rogaeva, Ekaterina ; George-Hyslop, Peter St. ; Rossi, Giacomina ; Tagliavini, Fabrizio ; Giaccone, Giorgio ; Rowe, James B. ; Schlachetzki, Johannes C. M. ; Uphill, James ; Collinge, John ; Mead, Simon ; Danek, Adrian ; Van Deerlin, Vivianna M. ; Grossman, Murray ; Trojanowski, John Q. ; van der Zee, Julie ; Cruts, Marc ; Van Broeckhoven, Christine ; Cappa, Stefano F. ; Leber, Isabelle ; Hannequin, Didier ; Golfier, Véronique ; Vercelletto, Martine ; Brice, Alexis ; Nacmias, Benedetta ; Sorbi, Sandro ; Bagnoli, Silvia ; Piaceri, Irene ; Nielsen, Jørgen E. ; Hjermind, Lena E. ; Riemenschneider, Matthias ; Mayhaus, Manuel ; Ibach, Bernd ; Gasparoni, Gilles ; Pichler, Sabrina ; Gu, Wei ; Rossor, Martin N. ; Fox, Nick C. ; Warren, Jason D. ; Spillantini, Maria Grazia ; Morris, Huw R. ; Rizzu, Patrizia ; Heutink, Peter ; Snowden, Julie S. ; Rollinson, Sara ; Richardson, Anna ; Gerhard, Alexander ; Bruni, Amalia C. ; Maletta, Raffaele ; Frangipane, Francesca ; Cupidi, Chiara ; Bernardi, Livia ; Anfossi, Maria ; Gallo, Maura ; Conidi, Maria Elena ; Smirne, Nicoletta ; Rademakers, Rosa ; Baker, Matt ; Dickson, Dennis W. ; Graff-Radford, Neill R. ; Petersen, Ronald C. ; Knopman, David ; Josephs, Keith A. ; Boeve, Bradley F. ; Parisi, Joseph E. ; Seeley, William W. ; Miller, Bruce L. ; Karydas, Anna M. ; Rosen, Howard ; van Swieten, John C. ; Dopper, Elise G. P. ; Seelaar, Harro ; Pijnenburg, Yolande A. L. ; Scheltens, Philip ; Logroscino, Giancarlo ; Capozzo, Rosa ; Novelli, Valeria ; Puca, Annibale A. ; Franceschi, Massimo ; Postiglione, Alfredo ; Milan, Graziella ; Sorrentino, Paolo ; Kristiansen, Mark ; Chiang, Huei-Hsin ; Graff, Caroline ; Pasquier, Florence ; Rollin, Adeline ; Deramecourt, Vincent ; Lebouvier, Thibaud ; Kapogiannis, Dimitrios ; Ferrucci, Luigi ; Pickering-Brown, Stuart ; Singleton, Andrew B. ; Hardy, John ; Momeni, Parastoo ; Zhao, Huashuo ; Zeng, Ping



Abstract

We employed Mendelian randomization (MR) to evaluate the causal relationship between leukocyte telomere length (LTL) and amyotrophic lateral sclerosis (ALS) with summary statistics from genome-wide association studies (n=similar to 38,000 for LTL and similar to 81,000 for ALS in the European population; n=similar to 23,000 for LTL and similar to 4,100 for ALS in the Asian population). We further ...

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