Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

URN to cite this document:: urn:nbn:de:bvb:355-epub-498447
DOI to cite this document:: 10.5283/epub.49844

Feldker, Nora ; Ferrazzi, Fulvia ; Schuhwerk, Harald ; Widholz, Sebastian A.

; Guenther, Kerstin ; Frisch, Isabell ; Jakob, Kathrin ; Kleemann, Julia ; Riegel, Dania ; Bönisch, Ulrike ; Lukassen, Sören

; Eccles, Rebecca L. ; Schmidl, Christian ; Stemmler, Marc P. ; Brabletz, Thomas ; Brabletz, Simone

License: Creative Commons Attribution Non-commercial No Derivatives 4.0
PDF - Published Version
(2MB)

Date of publication of this fulltext: 11 Oct 2021 12:46

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Invasion, metastasis and therapy resistance are the major cause of cancer-associated deaths, and theEMT-inducing transcription factorZEB1 is a crucial stimulator of these processes. While work onZEB1 has mainly focused on its role as a transcriptional repressor, it can also act as a transcriptional activator. To further understand these two modes of action, we performed a genome-wideZEB1 binding ...