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Genome‐wide cooperation of EMT transcription factor ZEB 1 with YAP and AP ‐1 in breast cancer

Feldker, Nora ; Ferrazzi, Fulvia ; Schuhwerk, Harald ; Widholz, Sebastian A. ; Guenther, Kerstin ; Frisch, Isabell ; Jakob, Kathrin ; Kleemann, Julia ; Riegel, Dania ; Bönisch, Ulrike ; Lukassen, Sören ; Eccles, Rebecca L. ; Schmidl, Christian ; Stemmler, Marc P. ; Brabletz, Thomas ; Brabletz, Simone



Abstract

Invasion, metastasis and therapy resistance are the major cause of cancer-associated deaths, and theEMT-inducing transcription factorZEB1 is a crucial stimulator of these processes. While work onZEB1 has mainly focused on its role as a transcriptional repressor, it can also act as a transcriptional activator. To further understand these two modes of action, we performed a genome-wideZEB1 binding ...

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