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Upconversion nanoparticles as intracellular pH messengers

Tsai, Evaline S. ; Joud, Fadwa ; Wiesholler, Lisa M. ; Hirsch, Thomas ; Hall, Elizabeth A. H.


Upconversion nanoparticles (UCNPs) should be particularly well suited for measurement inside cells because they can be imaged down to submicrometer dimensions in near real time using fluorescence microscopy, and they overcome problems, such as photobleaching, autofluorescence, and deep tissue penetration, that are commonly encountered in cellular imaging applications. In this study, the ...


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