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Differential localization of PD-L1 and Akt-1 involvement in radioresistant and radiosensitive cell lines of head and neck squamous cell carcinoma

Schulz, Daniela ; Streller, Melanie ; Piendl, Gerhard ; Brockhoff, Gero ; Reichert, Torsten E. ; Menevse, Ayse N. ; Beckhove, Philipp ; Hautmann, Matthias G. ; Bauer, Richard J. ; Ettl, Tobias


Immunotherapy by blockade of the PD-1/PD-L1 checkpoint demonstrated amazing tumor response in advanced cancer patients including head and neck squamous cell carcinoma (HNSCC). However, the majority of HNSCC patients still show little improvement or even hyperprogression. Irradiation is currently investigated as synergistic treatment modality to immunotherapy as it increases the number of T-cells ...


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