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Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia

Bengel, Philipp ; Ahmad, Shakil ; Tirilomis, Petros ; Trum, Maximilian ; Dybkova, Nataliya ; Wagner, Stefan ; Maier, Lars S. ; Hasenfuß, Gerd ; Sossalla, Samuel



Abstract

Objective: In myocardial pathology such as heart failure a late sodium current (I-NaL) augmentation is known to be involved in conditions of arrhythmogenesis. However, the underlying mechanisms of the I-NaL generation are not entirely understood. By now evidence is growing that non-cardiac sodium channel isoforms could also be involved in the I-NaL generation. The present study investigates the ...

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