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KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway

Sousa, Luis ; Pankonien, Ines ; Clarke, Luka A ; Silva, Iris ; Kunzelmann, Karl ; Amaral, Margarida D



Abstract

Cystic Fibrosis (CF) is caused by >2000 mutations in the CF transmembrane conductance regulator (CFTR) gene, but one mutation-F508del-occurs in similar to 80% of patients worldwide. Besides its main function as an anion channel, the CFTR protein has been implicated in epithelial differentiation, tissue regeneration, and, when dysfunctional, cancer. However, the mechanisms that regulate such ...

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