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Loss of CHEK2 Predicts Progression in Stage pT1 Non-Muscle-Invasive Bladder Cancer (NMIBC)

Spachmann, Philipp J. ; Azzolina, Vanessa ; Weber, Florian ; Evert, Matthias ; Eckstein, Markus ; Denzinger, Stefan ; Burger, Maximilian ; Otto, Wolfgang ; Breyer, Johannes


Downregulation of checkpoint protein kinase 2 (CHEK2), which is involved in DNA repair, is associated with poorer outcome in various tumors. Little is known about the role of CHEK2 in urothelial carcinoma of the bladder (UCB). In the present study, we investigated the prognostic impact of CHEK2 protein expression in stage pT1 UCB. This retrospective, single-center analysis was carried out in a ...


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