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Incidence of Anicteric Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome and Outcomes with Defibrotide following Hematopoietic Cell Transplantation in Adult and Pediatric Patients

Corbacioglu, Selim ; Kernan, Nancy A. ; Pagliuca, Antonio ; Ryan, Robert J. ; Tappe, William ; Richardson, Paul G.



Abstract

Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a potentially life-threatening complication of hematopoietic cell transplantation (HCT) that is traditionally diagnosed using Baltimore or modified Seattle criteria. Whereas the Baltimore criteria require the presence of hyperbilirubinemia (bilirubin >= 2 mg/dL) for a diagnosis of VOD/SOS, the modified Seattle criteria do not. ...

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