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Collecting system–specific deletion of Kcnj10 predisposes for thiazide- and low-potassium diet–induced hypokalemia

Penton, David ; Vohra, Twinkle ; Banki, Eszter ; Wengi, Agnieszka ; Weigert, Maria ; Forst, Anna-Lena ; Bandulik, Sascha ; Warth, Richard ; Loffing, Johannes


The basolateral potassium channel KCNJ10 (Kir4.1), is expressed in the renal distal convoluted tubule and controls the activity of the thiazide-sensitive sodium chloride cotransporter. Loss-of-function mutations of KCNJ10 cause EAST/SeSAME syndrome with salt wasting and severe hypokalemia. KCNJ10 is also expressed in the principal cells of the collecting system. However, its pathophysiological ...


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