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Luminescent Pyrimidine Hydrazide Oligomers with Peptide Affinity

Li, X., Miltschitzky, Stefan and König, B. (2006) Luminescent Pyrimidine Hydrazide Oligomers with Peptide Affinity. Bioorganic & Medicinal Chemistry 14, 6075 -6084.

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The modular synthesis of pyrimidine oligohydrazides and their peptide binding ability are reported. Ethylene glycol substituents ensure water solubility of the compounds. The pattern of hydrogen bond donors and hydrogen bond acceptors resembles the functionalities of a peptide backbone, and intramolecular hydrogen bonds restrict conformational mobility. The pyrimidine heterocycles show emission ...


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Item type:Article
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
16714117PubMed ID
Keywords:Peptide mimics; Pyrimidine; Hydrazine acid; Luminescence; FRET
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:50
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