Exome sequencing in 38 patients with intracranial aneurysms and subarachnoid hemorrhage

URN to cite this document:: urn:nbn:de:bvb:355-epub-500348
DOI to cite this document:: 10.5283/epub.50034

Sauvigny, Thomas ; Alawi, Malik ; Krause, Linda

; Renner, Sina ; Spohn, Michael ; Busch, Alice ; Kolbe, Verena ; Altmüller, Janine ; Löscher, Britt-Sabina ; Franke, Andre ; Brockmann, Christian ; Lieb, Wolfgang ; Westphal, Manfred ; Schmidt, Nils Ole

; Regelsberger, Jan ; Rosenberger, Georg

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 11 Oct 2021 12:50

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Abstract

Objective Genetic risk factors for unruptured intracranial aneurysms (UIA) and aneurysmal subarachnoid hemorrhage (aSAH) are poorly understood. We aimed to verify recently reported risk genes and to identify novel sequence variants involved in the etiology of UIA/aSAH. Methods We performed exome sequencing (ES) in 35 unrelated individuals and 3 family members, each with a history of UIA and/or ...