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Particle filter de-noising of voxel-specific time-activity-curves in personalized 177Lu therapy

Götz, Theresia I. ; Lang, Elmar W. ; Schmidkonz, Christian ; Maier, Andreas ; Kuwert, Torsten ; Ritt, Philipp


Background: Currently, there is a high interest in Lu-177 targeted radionuclide therapies, which could be attributed to favorable results obtained from Lu-177 compounds targeting neuro-endocrine and prostate tumors. SPECT based dosimetry could be used for deriving dose values for individual voxels, as is the standard in external-beam radiation-therapy (EBRT). For this a time-activity-curve (TAC) ...


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