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Shear Stress–Induced miR-143-3p in Collateral Arteries Contributes to Outward Vessel Growth by Targeting Collagen V-α2

Troidl, Kerstin ; Hammerschick, Thomas ; Albarran-Juarez, Julian ; Jung, Georg ; Schierling, Wilma ; Tonack, Sarah ; Krüger, Marcus ; Matuschke, Benjamin ; Troidl, Christian ; Schaper, Wolfgang ; Schmitz-Rixen, Thomas ; Preissner, Klaus T. ; Fischer, Silvia



Abstract

Objective: Arteriogenesis, describing the process of collateral artery growth, is activated by fluid shear stress (FSS). Since this vascular mechanotransduction may involve microRNAs (miRNAs), we investigated the FSS-induced expression of vascular cell miRNAs and their functional impact on collateral artery growth during arteriogenesis. Approach and Results: To this end, rats underwent femoral ...

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