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Randomized Sirolimus-based Early Calcineurin Inhibitor Reduction in Liver Transplantation: Impact on Renal Function

Buchholz, Bettina M. ; Ferguson, James W. ; Schnitzbauer, Andreas A. ; Nightingale, Peter ; Schlitt, Hans J. ; Geissler, Edward K. ; Mirza, Darius F.


Background. The long-term use of calcineurin inhibitors (CNIs) after liver transplantation (LT) is associated with nephrotoxicity. Methods. Five-year follow-up data were retrieved from the randomized controlled multicenter SiLVER trial. Standard CNI-based mammalian target of rapamycin-free immunosuppression (group A, n = 264) was compared with a 50% reduction of CNI and introduction of the ...


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