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Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in situ

Koscsó, Balázs ; Kurapati, Sravya ; Rodrigues, Richard R. ; Nedjic, Jelena ; Gowda, Kavitha ; Shin, Changsik ; Soni, Chetna ; Ashraf, Azree Zaffran ; Purushothaman, Indira ; Palisoc, Maryknoll ; Xu, Sulei ; Sun, Haoyu ; Chodisetti, Sathi Babu ; Lin, Eugene ; Mack, Matthias ; Kawasawa, Yuka Imamura ; He, Pingnian ; Rahman, Ziaur S. M. ; Aifantis, Iannis ; Shulzhenko, Natalia ; Morgun, Andrey ; Bogunovic, Milena



Zusammenfassung

Intestinal mononuclear phagocytes (MPs) are composed of heterogeneous dendritic cell (DC) and macrophage subsets necessary for the initiation of immune response and control of inflammation. Although MPs in the normal intestine have been extensively studied, the heterogeneity and function of inflammatory MPs remain poorly defined. We performed phenotypical, transcriptional, and functional analyses ...

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