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Treosulfan–fludarabine–thiotepa-based conditioning treatment before allogeneic hematopoietic stem cell transplantation for pediatric patients with hematological malignancies

Kalwak, Krzysztof ; Mielcarek, Monika ; Patrick, Katharine ; Styczynski, Jan ; Bader, Peter ; Corbacioglu, Selim ; Burkhardt, Birgit ; Sykora, Karl Walter ; Drabko, Katarzyna ; Gozdzik, Jolanta ; Fagioli, Franca ; Greil, Johann ; Gruhn, Bernd ; Beier, Rita ; Locatelli, Franco ; Müller, Ingo ; Schlegel, Paul Gerhardt ; Sedlacek, Petr ; Stachel, Klaus Daniel ; Hemmelmann, Claudia ; Möller, Ann-Kristin ; Baumgart, Joachim ; Vora, Ajay



Zusammenfassung

Treosulfan-based conditioning prior to allogeneic transplantation has been shown to have myeloablative, immunosuppressive, and antineoplastic effects associated with reduced non-relapse mortality (NRM) in adults. Therefore, we prospectively evaluated the safety and efficacy of treosulfan-based conditioning in children with hematological malignancies in this phase II trial. Overall, 65 children ...

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