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Myeloablative conditioning for allo-HSCT in pediatric ALL: FTBI or chemotherapy?—A multicenter EBMT-PDWP study

Willasch, Andre Manfred ; Peters, Christina ; Sedláček, Petr ; Dalle, Jean-Hugues ; Kitra-Roussou, Vassiliki ; Yesilipek, Akif ; Wachowiak, Jacek ; Lankester, Arjan ; Prete, Arcangelo ; Hamidieh, Amir Ali ; Ifversen, Marianne ; Buechner, Jochen ; Kriván, Gergely ; Hamladji, Rose-Marie ; Diaz-de-Heredia, Cristina ; Skorobogatova, Elena ; Michel, Gérard ; Locatelli, Franco ; Bertaina, Alice ; Veys, Paul ; Dupont, Sophie ; Or, Reuven ; Güngör, Tayfun ; Aleinikova, Olga ; Sufliarska, Sabina ; Sundin, Mikael ; Rascon, Jelena ; Kaare, Ain ; Nemet, Damir ; Fagioli, Franca ; Klingebiel, Thomas Erich ; Styczynski, Jan ; Bierings, Marc ; Nagy, Kálmán ; Abecasis, Manuel ; Afanasyev, Boris ; Ansari, Marc ; Vettenranta, Kim ; Alseraihy, Amal ; Chybicka, Alicja ; Robinson, Stephen ; Bertrand, Yves ; Kupesiz, Alphan ; Ghavamzadeh, Ardeshir ; Campos, Antonio ; Pichler, Herbert ; Dalissier, Arnaud ; Labopin, Myriam ; Corbacioglu, Selim ; Balduzzi, Adriana ; Galimard, Jacques-Emmanuel ; Bader, Peter



Abstract

Although most children with acute lymphoblastic leukemia (ALL) receive fractionated total body irradiation (FTBI) as myeloablative conditioning (MAC) for allogeneic hematopoietic stem cell transplantation (allo-HSCT), it is an important matter of debate if chemotherapy can effectively replace FTBI. To compare outcomes after FTBI versus chemotherapy-based conditioning (CC), we performed a ...

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