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Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Mohty, Mohamad ; Malard, Florent ; Abecasis, Manuel ; Aerts, Erik ; Alaskar, Ahmed S. ; Aljurf, Mahmoud ; Arat, Mutlu ; Bader, Peter ; Baron, Frederic ; Basak, Grzegorz ; Bazarbachi, Ali ; Blaise, Didier ; Ciceri, Fabio ; Corbacioglu, Selim ; Dalle, Jean-Hugues ; Dignan, Fiona ; Fukuda, Takahiro ; Huynh, Anne ; Kuball, Jürgen ; Lachance, Silvy ; Lazarus, Hillard ; Masszi, Tamas ; Michallet, Mauricette ; Nagler, Arnon ; NiChonghaile, Mairead ; Okamoto, Shinichiro ; Pagliuca, Antonio ; Peters, Christina ; Petersen, Finn B. ; Richardson, Paul G. ; Ruutu, Tapani ; Saber, Wael ; Savani, Bipin N. ; Soiffer, Robert ; Styczynski, Jan ; Wallhult, Elisabeth ; Yakoub-Agha, Ibrahim ; Duarte, Rafael F. ; Carreras, Enric



Abstract

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). While SOS/VOD may resolve within a few weeks in the majority of patients with mild-to-moderate disease, the most severe forms result in multiorgan dysfunction and are associated with a high mortality rate ...

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