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IL6-receptor antibody tocilizumab as salvage therapy in severe chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: a retrospective analysis

Kattner, Anna-Sophia ; Holler, Ernst ; Holler, Barbara ; Klobuch, Sebastian ; Weber, Daniela ; Martinovic, Danilo ; Edinger, Matthias ; Herr, Wolfgang ; Wolff, Daniel


Chronic graft-versus-host disease (cGvHD) remains the most relevant factor affecting survival after allogeneic hematopoietic stem cell transplantation (alloHSCT). Besides corticosteroids (and ibrutinib in the USA), there is no established therapy for cGvHD. Tocilizumab, a humanized IgG1 IL6-receptor antibody, has shown efficacy in acute GvHD and cGvHD. We retrospectively analyzed the efficacy and ...


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