Sparks, David S. ; Saifzadeh, Siamak 
; Savi, Flavia Medeiros ; Dlaska, Constantin E. ; Berner, Arne ; Henkel, Jan ; Reichert, Johannes C. ; Wullschleger, Martin ; Ren, Jiongyu ; Cipitria, Amaia ; McGovern, Jacqui A. ; Steck, Roland ; Wagels, Michael ; Woodruff, Maria Ann ; Schuetz, Michael A. ; Hutmacher, Dietmar W.
; Savi, Flavia Medeiros ; Dlaska, Constantin E. ; Berner, Arne ; Henkel, Jan ; Reichert, Johannes C. ; Wullschleger, Martin ; Ren, Jiongyu ; Cipitria, Amaia ; McGovern, Jacqui A. ; Steck, Roland ; Wagels, Michael ; Woodruff, Maria Ann ; Schuetz, Michael A. ; Hutmacher, Dietmar W. 
Zusammenfassung
This protocol describes how to establish an ovine critical-size, segmental bone defect model to study bone regeneration and reconstruction. Critical-size bone defects, which require large-volume tissue reconstruction, remain a clinical challenge. Bone engineering has the potential to provide new treatment concepts, yet clinical translation requires anatomically and physiologically relevant ...
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