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Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment

Mumuni, Momoh A. ; Calister, Ugwu E. ; Aminu, Nafiu ; Franklin, Kenechukwu C. ; Musiliu Oluseun, Adedokun ; Usman, Mohammed ; Abdulmumuni, Barikisu ; James, Oyeniyi Y. ; Ofokansi, Kenneth C. ; Anthony, Attama A. ; Ibezim, Emmanuel C. ; Díaz Díaz, David



Abstract

In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. ...

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