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Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment

A. Mumuni, Momoh ; E. Calister, Ugwu ; Aminu, Nafiu ; C. Franklin, Kenechukwu ; Musiliu Oluseun, Adedokun ; Usman, Mohammed ; Abdulmumuni, Barikisu ; Y. James, Oyeniyi ; C. Ofokansi, Kenneth ; A. Anthony, Attama ; C. Ibezim, Emmanuel ; Díaz Díaz, David



Abstract

In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. ...

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