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The macro-metastasis/organ parenchyma interface (MMPI) - A hitherto unnoticed area

Blazquez, R. ; Sparrer, D. ; Wendl, C. ; Evert, M. ; Riemenschneider, M. J. ; Krahn, M. P. ; Erez, N. ; Proescholdt, M. ; Pukrop, T.


The macro-metastasis/organ parenchyma interface (MMPI) was previously considered an inert anatomical border which sharply separates the affected organ parenchyma from the macro-metastatic tissue. Recently, infiltrative growth of macro-metastases from various primary tumors was described in the brain, liver and lung, with significant impact on survival. Strikingly, the MMPI patterns differed ...


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