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Insulin-loaded mucoadhesive nanoparticles based on mucin-chitosan complexes for oral delivery and diabetes treatment

Mumuni, Momoh A. ; Kenechukwu, Franklin C. ; Ofokansi, Kenneth C. ; Attama, Anthony A. ; Díaz, David Díaz



Abstract

In this study, insulin-loaded nanoparticles (NPs) were prepared via self-gelation method using chitosan and aqueous soluble snail mucin as natural polymers. Herein, mucins were ionically interacted with chitosan at different concentrations to obtained insulin-loaded NPs, labelled as Al (1:1) (Le., chitosan 2 % w/v + mucin 2 0/0 w/v) and A2 (2:1) (chitosan 4 % w/v + mucin 2 % w/v), using poloxamer ...

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