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Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans

Schlosser, Pascal ; Li, Yong ; Sekula, Peggy ; Raffler, Johannes ; Grundner-Culemann, Franziska ; Pietzner, Maik ; Cheng, Yurong ; Wuttke, Matthias ; Steinbrenner, Inga ; Schultheiss, Ulla T. ; Kotsis, Fruzsina ; Kacprowski, Tim ; Forer, Lukas ; Hausknecht, Birgit ; Ekici, Arif B. ; Nauck, Matthias ; Völker, Uwe ; Walz, Gerd ; Oefner, Peter J. ; Kronenberg, Florian ; Mohney, Robert P. ; Köttgen, Michael ; Suhre, Karsten ; Eckardt, Kai-Uwe ; Kastenmüller, Gabi ; Köttgen, Anna



Abstract

The kidneys integrate information from continuous systemic processes related to the absorption, distribution, metabolism and excretion (ADME) of metabolites. To identify underlying molecular mechanisms, we performed genome-wide association studies of the urinary concentrations of 1,172 metabolites among 1,627 patients with reduced kidney function. The 240 unique metabolite-locus associations ...

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