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Critical design criteria for engineering a nanoparticulate HIV-1 vaccine

Thalhauser, Stefanie ; Peterhoff, David ; Wagner, Ralf ; Breunig, Miriam



Abstract

Inducing a long-lasting as well as broad and potent immune response by generating broadly neutralizing antibodies is a major goal and at the same time the main challenge of preventive HIV-1 vaccine design. Immunization with soluble, stabilized and native-like envelope (Env) glycoprotein so far only led to low neu-tralization breadth and displayed low immunogenicity. A promising approach to ...

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