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Cytotoxic T-cell-related gene expression signature predicts improved survival in muscle-invasive urothelial bladder cancer patients after radical cystectomy and adjuvant chemotherapy

Eckstein, Markus ; Strissel, Pamela ; Strick, Reiner ; Weyerer, Veronika ; Wirtz, Ralph ; Pfannstiel, Carolin ; Wullweber, Adrian ; Lange, Fabienne ; Erben, Philipp ; Stoehr, Robert ; Bertz, Simone ; Geppert, Carol Imanuel ; Fuhrich, Nicole ; Taubert, Helge ; Wach, Sven ; Breyer, Johannes ; Otto, Wolfgang ; Burger, Maximilian ; Bolenz, Christian ; Keck, Bastian ; Wullich, Bernd ; Hartmann, Arndt ; Sikic, Danijel



Abstract

Background Assessment of the immune status of muscle-invasive bladder cancer (MIBC) has previously shown to be prognostically relevant after treatment with curative intent. We conducted this study to develop a clinically applicable immune gene expression assay to predict prognosis and adjuvant chemotherapy benefit. Patients and methods Gene expression of CD3Z, CD8A and CXCL9, immune cell (IC) ...

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